Publisher's Synopsis
As with all science, methods, systematic approaches and tools are evidences for success. This certainly applies to translational medicine. Translational Medicine is innovation toward achieving the conversion of knowledge and research breakthroughs stemming from the bench into clinical practices with the ultimate goal of improving patient outcomes. Translational Medicine is achieved through cross-disciplinary exchanges to overcome the traditional silos within the medical disciplines. Importantly, while clinical research has been in the past observational, the advent of new diagnostic tools and technologies, has enabled the systematic, multiparameter monitoring of large patient cohorts and introduced the next phase of Translational Medicine, with clinical research leading to mechanistic discoveries; however, there are many challenges and road blocks on the way that must be addressed In industry, as both preclinical and clinical studies have been performed routinely and professionally long before this call for translational activities emerged, now the major task is the intertwining and alignment of preclinical and clinical studies along the artificially straight drug discovery and development process. Here, it is more of an interface problem, than reflecting the lack of access to clinical trials. The main drawback of translational studies and related personalized medicine approaches in industry is the mandatory economical interest which is not in line with all sophistications of drug profiling leading to narrowed windows of opportunities. Translational Medicine - What, Why and How: An International Perspective covers all areas of translational medicine focusing on information derived from human experimentation so as to optimize the communication between basic and clinical science. New ideas, hypothesis-driven perspectives, and reviews on any particular aspects of hematology are also outlined that such contributions will provide the platform for further discussions and hypothesis-testing to hasten our efforts to seamlessly bring successes from bench to bedside. This book will be of valued to life science researchers, engineers, clinical researchers, and clinical practitioners.
