Publisher's Synopsis
Excerpt from Transactions and Studies of the College of Physicians of Philadelphia, 1941-42, Vol. 9
Although the disease has almost uni versally been regarded as the expression of infection of the colonic wall, other mechanisms have had their proponents. Food allergy has been shown to play an important role in certain cases Psychogenic factors operating through the vegetative nervous system to pro duce hyperperistalsis and surface diges tion of the mucosa have been held re sponsible The demonstration that persistent spasm of the musculature of externalized portions of the colon of experimental animals leads progressively to congestion of the mucosa, bleeding, and finally ulceration (9) indicates that the autonomic nervous system unquestion ably plays an important role. This is further supported by clinical evidence to which reference will be made subse quently. None of these hypotheses, how ever, explain the clinical course of the disease, nor do they provide the thera peutic indications which permit of check ing the acute attack and of preventing recurrence.
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