Publisher's Synopsis
Excerpt from The Elimination and Toxicity of Caffein in Nephrectomized Rabbits
Although it is known that alkaloids may be eliminated by the walls of the stomach and intestine in health, very few of them have been investigated m regard to their excretion into the intestines or stomach in abnormal conditions. As pointed out in a previous investigation 27 by this laboratory, studies on the elimination of caffein were made by a number of investigators, but for the reasons set forth its rein vestigation was undertaken. It was found that this substance is eliminated by the stomach and intestine as well as by the kidney, but the relative amounts found in the contents of the gastrointestinal canal, especially in the contents of the intestine, are greater with a diet of oats than with one of carrots. Since this difference in the rate of elimination may be accounted for by the increased activity of the kidney on a diet of carrots, the desirability of testing the eliminative capacity of the gastrointestinal canal of the rabbit for caffein presented itself as affording an Opportunity to test the exist ence of a compensatory mechanism for the elimination of caffein after the removal of both kidneys.
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