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TDP-43 and Neurodegeneration

TDP-43 and Neurodegeneration From Bench to Bedside

Paperback (27 Oct 2021)

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Publisher's Synopsis

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43's structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.

Book information

ISBN: 9780128200667
Publisher: Elsevier Science
Imprint: Academic Press
Pub date:
DEWEY: 616.80471
DEWEY edition: 23
Language: English
Number of pages: 300
Weight: 446g
Height: 154mm
Width: 228mm
Spine width: 18mm