Studies in Osteoarthrosis Pathogenesis, Intervention, Assessment

Studies in Osteoarthrosis Pathogenesis, Intervention, Assessment Edited By D.J.Lott–M.K.Jasani–G.F.B.Birdwood For a common disabling condition osteoarthrosis gives rise to a surprisingly broad range of questions—from causation to its possible prevention or cure—that have yet to be fully resolved. It is imperative that we should learn more about the mechanisms by which joint damage occurs if we are to achieve the ultimate aim of intervening to prevent these destructive processes. Meanwhile, certain treatments couple symptomatic relief with some protection against progressive joint deterioration. Presented here is an authoritative collection of well illustrated anatomical and biochemical studies in both man and in animal models, reflecting the current state of knowledge. The focus is on three clear areas: the nature of processes that mediate joint damage in OA, the means available for intervening in these processes, and the limitations of present methods for assessing joint changes. Taken together, papers on these topics should facilitate understanding of the natural history of OA and the benefits of intervention, whether in individual patients or in clinical trials. These studies represent a major contribution to the understanding of osteoarthrosis. They should stimulate research and prove of practical value to all clinicians responsible for treating patients with this widespread disorder.