Publisher's Synopsis
Toxicity testing of chemicals in experimental animals to detect potential hazards to human health and the environment has been for decades the cornerstone of national and international programmes on chemical safety. Over the last several years, major advances in the biological and medical sciences have led to the development of new short-term tests for non-genotoxic end-points. Although many of these tests hold great promise for improving the risk assessment process, as well as for decreasing the use of experimental animals in toxicology, the relevance to the intact animal of the scientific data obtained from such short-term tests have yet to be evaluated.;The fourth workshop of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC) was organized to address such important scientific issues, providing assistance to the scientific community to develop new and improved methods for assessing risks from chemical exposures.
