Relevance of Animal Studies to the Evaluation of Human Cancer Risk Proceedings of a Symposium Held December 5-8, 1990 in Austin, Texas - Progress in Clinical and Biological Research

Progress in Clinical and Biological Research, Volume 374 Relevance of Animal Studies to the Evaluation of Human Cancer Risk Proceedings of a Symposium held December 5–8, 1990 in Austin, Texas Robert D’Amato, Thomas J. Slaga, William H. Farland, and Carol Henry, Editors The carcinogen bioassay in rodents has been a preferred method of screening chemicals for carcinogenicity for several decades. The reliability of this methodology has recently come under scrutiny, however, raising scientific and social value issues and necessitating a re–evaluation of this approach toward assessing human risk. Relevance of Animal Studies to the Evaluation of Human Cancer Risk offers an authoritative review of research trends and current issues in carcinogenesis and risk management. The book focuses on five categories of case studies comparing human and animal data as a means of understanding the factors that are crucial to the action of carcinogens in humans: physical carcinogens with both strong experimental animal and human data; chemical carcinogens with both strong experimental animal and human data; chemotherapeutic agents and secondary tumors; drugs and environmental tumors; and carcinogenic enhancing agents and/or tumor promoters. Highlighting major scientific and research issues as they relate to these case studies, Relevance of Animal Studies to the Evaluation of Human Cancer Risk features in–depth discussion and review of such topics as:

• carcinogenic effects of certain chemotherapeutic agents, alkylating agents, and their relation to carcinogenesis
• interspecies sensitivity to important chemical carcinogens and their possible mechanism of action in each species
• animal inhalation studies to assess the risk of pulmonary cancer induced by mineral fiber
• benzene dosimetry in experimental animals and molecular dosimetry of aflatoxin DNA adducts in humans and rats
• cancer enhancement by cell proliferation

Spectacular increases in the amount of information available on cancer biology and pathogenesis make Relevance of Animal Studies to the Evaluation of Human Cancer Risk an especially timely and useful compilation and an essential reference for cancer and radiation biologists, toxicologists, pharmacologists, biochemists, and molecular and cellular biologists, as well as any scientist involved in the study of environmental health hazards.