Publisher's Synopsis
TAR DNA-binding protein 43 (TDP-43) is a protein that is involved in the pathology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In patients with these neurodegenerative diseases, TDP-43 does not remain in its normal nuclear location, but instead forms insoluble aggregates in both the nucleus and cytoplasm of affected neurons. Our results suggest that TDP-43 aggregation is associated with the cell death process rather than being a direct cause. Proceeds from the sale of this book go to support an elderly disabled person.
