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Protein Instability at Interfaces During Drug Product Development

Protein Instability at Interfaces During Drug Product Development Fundamental Understanding, Evaluation, and Mitigation - AAPS Advances in the Pharmaceutical Sciences Series

Paperback (13 Feb 2022)

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Publisher's Synopsis

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity.  This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in thesurface science, pharmaceutical, and medicinal chemistry areas.

 

Book information

ISBN: 9783030571795
Publisher: Springer International Publishing
Imprint: Springer
Pub date:
DEWEY: 615.19
DEWEY edition: 23
Language: English
Number of pages: 338
Weight: 534g
Height: 235mm
Width: 155mm
Spine width: 18mm