Publisher's Synopsis
Detal'no izucheny osobennosti funktsional'noy morfologii miokarda levogo zheludochka i ushka pravogo predserdiya u bol'nykh ishemicheskoy kardiomiopatiey, v tom chisle iz zon akineza, diskineza, gipokineza i normokineza levogo zheludochka. Vpervye sopostavleny rannie i otdalennye klinicheskie rezul'taty operativnogo lecheniya bol'nykh ishemicheskoy kardiomiopatiey s osobennostyami funktsional'noy morfologii miokarda ikh intraoperatsionnykh biopsiy i soderzhaniem v krovi kardiospetsifichnykh markerov, pozvolivshie fundamental'no obosnovat' sovremennuyu kontseptsiyu khirurgicheskogo lecheniya khronicheskoy serdechnoy nedostatochnosti. Vpervye pokazano, chto povtornoe remodelirovanie levogo zheludochka i progressirovanie khronicheskoy serdechnoy nedostatochnosti v otdalennom posleoperatsionnom periode u bol'nykh ishemicheskoy kardiomiopatiey mozhno dostoverno prognozirovat' na dooperatsionnom etape na osnovanii analiza morfofunktsional'nogo sostoyaniya miokarda (po dannym do- i intraoperatsionnykh biopsiy), a takzhe po soderzhaniyu matriksnykh metalloproteinaz v syvorotke krovi.
