Publisher's Synopsis
This text is designed to outline broad pharmacokinetic (PK) and pharmacodynamic (PD) principles which can be used to improve anticancer drug discovery, early phase testing, and later clinical use. Rather than presenting a compendium of data about individual drugs, the book shows how to use PK/PD principles to optimize therapy with established agents, or to evaluate the activity of new ones. An introductory section reviews critical derivation and application of PK/PD principles at various phases of preclinical and clinical drug development. The remaining sections focus on topics including cellular phenomena and molecular targets of drug action from the perspective of PK principles, dose and scheduling issues to optimize therapeutic activity, and implications of reactive intermediate formation for PK analysis, therapeutic effect, and toxicity. This book is a valuable resource for preclinical investigators of cancer therapeutics, such as pharmacologists and medicinal chemists, as well as clinical oncologists who are involved in the development of therapeutics and clinical trials or who may want to strategize how to use
