Publisher's Synopsis
This volume assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Abberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumour cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. The text presents concepts as well as experimental approaches, which define funtionality of nuclear morphology.
