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Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy : Targeted Therapies to Reverse Resistance

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy : Targeted Therapies to Reverse Resistance - Resistance to Targeted Anti-Cancer Therapeutics

Paperback (19 May 2015)

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Publisher's Synopsis

​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.

Book information

ISBN: 9781489988416
Publisher: Springer New York
Imprint: Springer
Pub date:
Language: English
Number of pages: 260
Weight: 4277g
Height: 235mm
Width: 155mm
Spine width: 15mm