Publisher's Synopsis
Excerpt from Mellon Lecture: Under the Auspices of the Society for Biological Research, University of Pittsburgh, Third Lecture; Recent Biochemical Investigations on Blood and Urine; Their Bearing on Clinical and Experimental Medicine
The speed with which a condition of approximate equilibrium is established between the blood and the tissues in the case of ordinary soluble products has never received the consideration and study that this phenomenon deserves. The literature abounds in explanations of clinical or metabolism problems based on the assumption that the blood is almost a closed system with reference to the general tissues of the body. I doubt not but that there is such a thing as selective affinity between this or that product and this or that tissue. There must be some specific cause, however, for every case of such selective accumula tion, for each case must be regarded as more or less Of an exception to a general rule.
As an interesting erroneous explanation of an impor tant metabolism problem based On a misconception as to the equilibrium phenomenon between the blood and the tissues may be mentioned the old hypothesis that creatin is the intermediate product in the breakdown of body protein into urea.
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