Publisher's Synopsis
A state–of–the–art presentation of the technology for studying human chromosomes. The book serves as a basic techniques manual designed to concisely present the current working protocols in cytogenetics. Beginning with a decription of tissue culture procedures for all tissue types from blood to solid tumors, subsequent chapters provide extensive coverage of chromosome preparations, differential staining techniques, chromosome sorting, high–resolution banding, fragile X analysis, sister chromatoid exchanges and DNA replication. A new chapter entitled "Molecular Cytogenetic Techniques" covers the latest fluorescent in–site hybridization (FISH) procedures illustrated by 20 colour plates. Summarizes latest research on the structure, organization, function, and regulation of ion channels in the cardiovascular system. This text deals with the fundamental biology and clinical implications of the function and dysfunction of major ion channel types. Particular focus is given to channels in the heart. The material presented will provide an increased understanding of channel biology and provide a stronger interdisciplinary appreciation of its potential role in treating cardiovascular disease.
