Publisher's Synopsis
This book deals with two fundamental issues of ion channels the gating kinetics problem and the nano–scale ion permeation problem. The gating kinetics problem seeks to explain how to construct probabilistic models for the on–off switching of ion channels. The second part of the book deals with the permeation problem, which seeks to explain how individual ions propagate through the membrane nano–tube at an Angstrom unit spatial resolution and femto–second time scale.