Inorganic Biochemistry of Iron Metabolism From Molecular Mechanisms to Clinical Consequences

Iron is of fundamental importance for the growth, development and well being of almost all living organisms. Multiple biological systems have been developed for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. e.g. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies; iron has a well established role in infections by a wide range of microorganisms and parasites; there is a close link between iron requirements and cellular division with implications for cancers and other metals such as copper and zinc are closely linked with iron metabolism. The first edition of this book was published in 1991 and since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of its homeostasis. The explosive use of molecular biological techniques applied to cellular biology of iron metabolism has resulted in a rapid expansion in the literature that has led to the need for this second edition.;This collaboration between five specialist authors covers the fundamental concepts and applied aspects of iron biochemistry. Completely updated it reflects the latest advances in the field and now includes new chapters on iron and cell division and the interactions of iron with other metals.;Exploring the chemistry, biology, biochemistry, physiology and medical aspects of iron in biological systems from microorganisms to man this essential title: Introduces illustrations and colour photos to make the basic concepts far clearer Includes new chapters on iron and cell division and interactions of iron with other metals - particularly copper and zinc Provides additional anecdotes Incorporates an extensive and up-to-date bibliography Covers both fundamental and applied aspects Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 2nd Edition is therefore essential to researchers interested in iron in the areas of: Biochemistry Molecular Biology Microbiology Cell Biology Nutrition and Medical Sciences University lecturers of: Bioinorganic Chemistry Inorganic Chemists interested in Biochemistry Biochemists with an interest in iron metabolism Health professionals with an interest in iron metabolism diseases Pharmacologists in drug companies interested in developing novel iron binding drugs