Inhibition of Matrix Metalloproteinases Therapeutic Potential - Annals of the New York Academy of Sciences

This volume comprises papers that deal with strategies of matrix metalloproteinases (MMPs), which have been implicated in human disease. These enzymes, including collagenase, gelatinase and stomelysin, appear to be pathologically increased in a wide variety of disease states such as rheumatoid and osteoarthritis, periodontal disease, diabetes, ophthalmologic conditions, neoplasia, dermatologic disorders, metabolic bone disease, and orthopedic conditions. Indentification of agents that might inhibit collagenase and other MMPs has been a therapeutic goal for modulation of connective tissue degradation. In view of the wide range of potential MMP inhibitors and the diversity of theoretically useful agents, experts from multidisciplinary fields discuss mechanisms of action and models for drug development.;The papers were presented at a conference entitled Inhibition of Matrix Metalloproteinases: Therapeutic Potential, 19-22 January, 1994, Tampa, Florida.