Publisher's Synopsis
A clear understanding of immunogenicity is necessary for the design of effective vaccines and the avoidance of unnatural immune responses. This study offers a thorough examination of the involved mechanisms of immunogenicity and its practical applications. It focuses on the events that lead to T-cell activation and memory generation, deals with the processing and presentation of antigens to T-cells, examines recognitive and signalling events and covers the processes surrounding lymphocyte activation. There is a full discussion of immunological memory and the role of immunogenicity in infectious diseases, vaccine design, transplantation immunity and autoimmunity.
