Publisher's Synopsis
This reference work evaluates the cellular and molecular basis of cancer as a disease of abnormal cell proliferation and discusses novel oncogenes included among the most interesting elements in the pathogenesis of human malignancy. The book examines the expanding role of secreted growth factor activities in malignant progression, featuring a report on fibroblast growth factors, a related family of growth factors that represent products of specific oncogenes. The volume reveals specific evidence for the participation of growth factors in autocrine and paracrine loops that contribute to tumor pathogenesis. It also presents systemic analyses of breast and lung cancers that underscore the complicated control of growth regulation for both normal and malignant cells.
