Publisher's Synopsis
Over the past several years, research efforts in the areas of tissue-specific gene expression and gene transfer have focused on the goal of conducting somatic gene therapy in humans.This book covers in detail a broad range of topics related to this important subject, from the perspectives of both basic researchers and human geneticists working with inheritable diseases. It reports the progress in gene transfer that has been made in various species, from Drosophila to higher mammals, including illustrative examples of germline gene transfer and tissue-specific somatic gene regulation in the mouse. Important new information regarding developmental control of gene transcription includes the delineation of distal elements, both cis and trans,controlling specific gene regulation.
