Publisher's Synopsis
Volume 9 continues the series "Frontiers in Biotransformation" with the intention to elucidate the transfer of molecular data of biotransformation to its application in molecular medicine. The scope of the 7 chapters spans from the isolation and transfer of genes into other species as models for studying the molecular origin of certain diseases till to the investigation of the molecular mechanism of induction by analysing the regulation of genes whose expressed proteins control the metabolism of drugs and their elimination. The knowledge of these processes is of multiple importance for a medicinal application. The heterologous transfer of the renin gene does not only enable insight into the molecular basis of the development of hypertension but also opens possibilities for an early diagnosis of this disease and for designing targeted drugs. This is also true concerning the investigation of mechanisms of induction which on the one hand is aimed at detecting the molecular reason of drug resistance in chemotherapy and on the other hand leads to a specific regulation of gene activity. These and other aspects of the gene as subject of investigation are discussed by experts active in the field. This volume may be of interest for clinicians and bioscientists working in research laboratories and in hospitals likewise.
