Publisher's Synopsis
Excerpt from Ethical Procedures in Comparative Evaluation of Drugs
The comparison of sampled distributions is one of the classical problems of statistics. Evaluation of any technique for doing so depends at least implicitly on an assumed cost function. In one of the most impor tant applications, that of choosing treatments for the ailments of man, costs are measured in suffering and death, and must be accorded primary importance. In this lecture, I would like to address a highly simplified but in fact prototypical situation of this kind. It is that in which two drugs, A and B, are available for a specified illness, their actions are unequivocal or dichotomic: success or failure, and this action is on a time scale short compared to that on which patients.
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