Publisher's Synopsis
Excerpt from Division of Intramural Research: Annual Report; October 1, 1988 September 30, 1989
The Division of Intramural Research has long been interested in understanding the molecular properties of the plasma lipoproteins, their biosynthesis, their role in lipid transport, and the molecular and morphological defects associated with disorders of lipid metabolism and atherogenesis (molecular Diseases, Pathology). Also, several aspects of myocardial ischemia are under study including the energy metabolism of the ischemic and postischemic heart and brain (cardiac Energetics, Surgery), the possibility that angina in the absence of coronary artery disease may, in some cases, be related to a generalized dysfunction of smooth muscle, and, in others, to abnormalities of endothelial function (cardiology); and the potential use of growth factors to enhance development of collateral coronary circulation (cardiology). Several Branches are collaborating on diverse studies of hypertrophic cardiomyopathy: identification of its genetic basis (clinical Hematology, Cardiology); the possibility of the involvement of abnormal calcium metabolism (cardiology); and improved operative treatment (surgery).
Several Laboratories are investigating related aspects of the processes of transmembrane signal transduction. Studies include the cleavage of phosphatidylinositol by the multiple isoforms of phospholipase C of mammalian brain (biochemistry); the mechanisms for control of the synthesis, assembly and operation of the guanine nucleotide-binding (g) proteins (cellular Metabolism); the role of the G-proteins and phosphoinositide pathways in mediating the antigen-induced release of histamine from mast cells (chemical Pharmacology); and the role of cyclic amp in regulating protein synthesis (biochemical Genetics).
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