Publisher's Synopsis
This book offers unique content for both basic and clinical scientists around the world with an interest in cell-surface peptidases. The book focuses on five cell-surface peptidases, namely neutral endopeptidase (NEP)/CD10, aminopeptidase N (APN)/CD13, aminopeptidase A (APA)/BP1, dipeptidyl peptidase IV (DPPIV)/CD26, and placental leucine aminopeptidase (PLAP)/insulin-regulated aminopeptidase (IRAP), which are members of the type II membrane-bound peptidase family. It reviews the recent progress in these peptidases as well as their peptide substrates, and explores their physiological and pathological significance. Key features include: a new insight into the regulation of blood pressure and peripheral vascular systems; research into a new mechanism for insulin-responsive glucose transport and its application for the treatment of diabetes; and understanding of the new mechanisms of cell-survival peptidase involvement in human tumor progression
