Publisher's Synopsis
Excerpt from Carbon Dioxide Production From Nerve Fibres When Resting and When Stimulated: A Dissertation Submitted to the Faculty of the Ogden Graduate School of Science in Candidacy for the Degree of Doctor of Philosophy, (Department of Physiology)
Although it has been established by repeated demonstrations, that the nerve does not fatigue under ordinary conditions, as measured by the method used in muscular studies, yet Frohlich 6 observed that the nerve undergoes certain changes by long activity. Gotch and Burch discovered7 in 1889 that if two stimuli are successively set up within of a second, only one negative variation is produced. This critical interval, or refractory period, is found to be altered by temperature changes, by drugs, asphyxiation, and anaesthetics.8 Thus by prolonging the refractory period by partial anaesthesia, froh lich easily demonstrated that with a frequency of stimulation less than this normal refractory period, stimulation of the attached muscle no longer occurred. He interprets this as a phenomenon of fatiga bility of the nerve. Thoner's 9 Observation seems to lead to a similar interpretation, for 'he found recently that fatigability is less effec tive when the refractory period is shortened by high temperature. There seems, then, to be fatigue in the nerve, but it cannot be measured by an ordinary scale.
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