Publisher's Synopsis
This book provides a straightforward account of the physiological mechanisms which regulate the concentration of calcium in the extracellular fluid, and the diseases which upset the homeostasis of calcium. In this revised and updated edition, new data concerning the mechanisms of hypercalcemia of malignancy, the calcium exchange mechanism between bone and extracellular fluid, PTH-related protein, interleukin-6 and the new generation of biospheres is presented. This volume also covers principles underlying calcium homeostasis and the roles of bone, kidney and gut, as well as major hormonal factors. Hypercalcemia of malignancy and hypercalcemia associated with osteolytic metastases and hematologic malignancies are also stressed. Throughout, the author examines causes, clinical features, differential diagnosis, and treatment. This excellent, accessible account is an outstanding reference for both practitioners and researchers.
