Publisher's Synopsis
Presenilin-1 (PS1) is the active component of the amyloid precursor protein cleaving gamma-secretase complex. PS1 protein is a transmembrane protein containing multiple hydrophobic regions which presence in cerebrospinal fluid (CSF) has not been measured to date. This study assesses whether PS1 and other components of the gamma-secretase complex are present in CSF. Our data suggest that fragments of the PS1 protein present in CSF as complexes may be useful as a biomarker for AD. Proceeds from the sale of this book go to the support of an elderly disabled person.
