Publisher's Synopsis
This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1915 edition. Excerpt: ...no more quickly than blood with an equal amount of added physiological salt solution. Also contrary to this claim are the following two experiments: (1) Ligatures were tied around the aorta and inferior vena cava immediately above the diaphragm, and thus the circulation was confined almost completely to the anterior part of the animal. Indeed, since the posterior part ceases to function in the absence of blood supply, the preparation may be called an "anterior animal." When such a preparation was made and 0.5 cubic centimeter of adrenin, 1:100,000 (half the usual dose, because, roughly, half an animal), was injected slowly into one of the jugulars, coagulation was not shortened. 'Whereas for a half-hour before the injection the clotting time averaged 4.6 minutes, for an hour thereafter the average was 5.3 minutes--a prolongation which may have been due, not to any influence of adrenin, but to failure of the blood to circulate through the intestines and liver.14 In another experiment after the gastrointestinal canal and liver had been removed from the animal, the average time for coagulation during twenty-five minutes before injecting adrenin (0.23 cubic centimeter, 1:100,000, in an animal weighing originally 2.3 kilos) was 5.5 minutes, and during forty minutes after the injection it was 6.8 minutes, with no case shorter than 6 minutes. In the absence of circulation through the abdominal viscera, therefore, adrenin fails to shorten the clotting time. (2) The cannulas were filled with adrenin, 1:1,000, and emptied just before being introduced into the artery. The small amount of adrenin left on the walls was thus automatically mixed with the drawn blood. Alternate observations with these cannulas wet by adrenin and with the usual dry...
