Publisher's Synopsis
Doctoral Thesis / Dissertation from the year 2008 in the subject Medicine - Neoplasms, Oncology, grade: 1.00, language: English, abstract: Centrally arising squamous cell carcinoma of the airway is thought to develop through multiple stages from squamous metaplasia to dysplasia, followed by carcinoma in situ (CIS), progressing to invasive cancer. It would be ideal to be able to detect and treat preinvasive bronchial lesions before progressing to invasive cancer. Advances in early diagnostic and treatment options have the potential to manage LC while still in an intraepithelial and/or microinvasive stage. WLB is one of the most commonly used diagnostic tools for LC. However, WLB is limited in its ability to detect small intraepithelial and microinvasive preinvasive lesions.AFB was developed to address this limitation by WLB. Indications for AFI examination; (1) Patients with known or suspected LC (2) Patients with abnormal sputum cytology (3) Patients after curative surgery for stage I LC(4) Current or former smokers with symptoms. A total of 74.7% patients had abnormal sputum cytology, 14.3% had known or suspected LC. All patients underwent conventional WLB followed by AFI examination; using the AFI device. Bronchoscopic-guided biopsy specimens were obtained. Sensitivity, specificity, and diagnostic accuracy of WLB versus that of AFI, were 58.3% Vs 88.9%; 46.7% Vs 71.9%; and 53.0% Vs 80.9%. with a very high significant difference (p value
