Publisher's Synopsis
This study reviews the global status of bacterial infections and resistance, and describes the mechanisms involved, the spread of antibiotic resistance and its reversibility. An international team of authors address theories and discoveries in bacterial resistance, including: the role of anitbiotic efflux mechanisms in resistance; the cost of resistance to bacteria and its use in reversing the spread of resistance; and the importance of low-level resistance in the early development of clinically relevant resistance. The final section of the book investigates modern techniques for the development of new drugs and highlights the importance of genomics and combinatorial chemistry in the search for new targets and antimicrobials.
