Publisher's Synopsis
The 23 articles in the 2008 edition of the annual series review recent findings in the study of biological function, organization, and structure by physical and physicochemical ideas and methods. A particularly lengthy chapter systemizes the role of intrinsically disordered proteins in cancer, Alzheimer's disease. Prion diseases, and type II diabetes. Other topics include mediation and modulation of membrane-cytoskeleton interactions, metal binding affinity and selectivity in metalloproteins, translocation and unwinding mechanisms of RNA and DNA helicases, and the structure of eukaryotic RNA polymerases.
