Publisher's Synopsis
Extending the work of the other titles in the "Airways Smooth Muscle" sub-series, this volume describes in detail current theories concerning the pharmacological control of airways smooth muscle tone. Particular emphasis is placed upon the expression and distribution of receptors that are activated by classical neurotransmitters, lipid mediators and amines. Additionally, special attention is directed to describing the various biochemical signalling pathways that are recruited by these molecules and how they may be manipulated pharmacologically.;Coverage includes chapters on histamine, leukotrienes, GABA and benzodiazepines and 5-hydroxytryptamine. The information presented should serve as a valuable foundation for understanding both current theories of receptor pharmacology and signal transduction, and provide a basis for drug therapy in treating respiratory disease such as asthma.;Reflecting the latest advances in this important area of respiratory research, this comprehensive and authoritative monograph should serve useful to pharmacologists, biochemists and clincians.
