Publisher's Synopsis
This volume on cancer research includes: a developmental model of progenitor cell oncogenesis based on a description of transcriptional control; pathways of chromosome alteration in human epthelial cancers, using colorectal, breast, lung and endometrial cancers as examples; the genetics of murine lung tumours; the molecular pathogenesis of AIDS-related lymphomas; HLA class I antigens in human tumours, focusing on abnormal MHC expression detected in human tumours and the biological role these alterations may have in tumour development; a summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission and pathogenesis. Two reviews discuss angiogenesis: the first focuses on the role of scatter factor, and the second on the VEGF-FH receptor system.
