Publisher's Synopsis
Alzheimer's disease (AD) is characterized by the deposition of insoluble amyloid plaques in the neuropil composed of highly stable, self-assembled Amyloid-beta (Abeta) fibrils. Copper has been implicated to play a role in Alzheimer's disease. Dimers of Abeta have been isolated from AD brain and have been shown to be neurotoxic. Abeta dimers may be stabilized by dityrosine crosslinking. These results indicate that dityrosine cross-links may play an important role in the pathogenesis of Alzheimer's disease and can be generated by reactive oxygen species catalyzed by Cu 2+ ions. The observation of increased Abeta and dityrosine in CSF from AD patients suggests that this could be used as a potential biomarker of oxidative stress in AD. Proceeds from the sale of this book go to the support of an elderly disabled person.
